Gilead Oncology Triple Negative Subtypes | GileadPro

Triple-negative breast cancer is a clinically challenging disease, partly due to its molecular heterogeneity.¹

Genomic profiling of cancer cells has revealed six distinct subtypes: Basal-like 1 (BL1), basal-like 2 (BL2), mesenchymal (M), mesenchymal stem-like (MSL), immunomodulatory (IM), and luminal androgen receptor (LAR).²

Basal-like breast cancers, which are intrinsically more aggressive forms of the disease, have the most substantial overlap with triple-negative breast cancer. BRCA1 mutations are frequent among patients with both of these cancer types.¹

Triple-negative breast cancer subtypes and genomics

Dr Mark Harries, Consultant Medical Oncologist, Guy’s and St Thomas’ Hospitals Foundation Trust, summarises molecular subtypes and genomic pathway aberrations in triple-negative breast cancer.

(01:57 minutes)

References:

1. Yin L, et al. Breast Cancer Res. 2020;22(1):61.
2. Lehmann BD, Pietenpol JA. J Pathol. 2014;232(2):142-150.